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KMID : 1134820130420010026
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Journal of the Korean Society of Food Science and Nutrition
2013 Volume.42 No. 1 p.26 ~ p.32
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Fingerroot (Boesenbergia pandurata) Extract Inhibits the Accumulation of Visceral Fat in C57BL/6J Mice
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Myuong Kil-Sun
Ahn Young-Tae
Lee Myoung-Hee
Park Do-Young
Ahn Young-Min
Huh Chul-Sung
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Abstract
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Boesenbergia pandurata (Roxb.) Schltr. has been reported to possess anti-oxidative and anti-inflammatory properties. The aim of this study was to investigate the effect of Boesenbergia pandurata extract (BPE) in a high-fat diet (HFD)-induced obese mice model. C57BL/6J mice were fed with either the high-fat diet or a 0.5% BPE-supplemented HFD for 8 weeks. The BPE-containing HFD significantly reduced body weight gain and the accumulation of visceral fat mass in mice model without altering the amount of food intake. Moreover, mice fed with BPE-containing HFD had lower concentrations of lipids in their blood, lower hepatic lipid accumulation, and lower serum leptin levels compared with the HFD-fed mice. RT-PCR analysis showed that the expression levels of peroxisome proliferators-activated receptor γ2 (PPARγ2) and CCAT/enhancer binding protein α (C/EBPα) genes in the epididymal fat tissue of mice fed the BPE-containing HFD increased 1.16- and 1.30-fold, respectively, compared to mice fed HFD only. In conclusion, BPE attenuated visceral fat accumulation and improved dyslipidemia in a mice model with HFD-induced obesity.
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KEYWORD
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Boesenbergia pandurata, fingerroot, obesity, high-fat diet, visceral adiposity
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